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  5. Volume 5, Issue 1 (2018)
  6. Confidence regions in Cox proportional h ...

Modern Stochastics: Theory and Applications

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Confidence regions in Cox proportional hazards model with measurement errors and unbounded parameter set
Volume 5, Issue 1 (2018), pp. 37–52
Oksana Chernova   Alexander Kukush  

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https://doi.org/10.15559/18-VMSTA94
Pub. online: 31 January 2018      Type: Research Article      Open accessOpen Access

Received
16 January 2018
Revised
17 January 2018
Accepted
17 January 2018
Published
31 January 2018

Abstract

Cox proportional hazards model with measurement errors is considered. In Kukush and Chernova (2017), we elaborated a simultaneous estimator of the baseline hazard rate $\lambda (\cdot )$ and the regression parameter β, with the unbounded parameter set $\varTheta =\varTheta _{\lambda }\times \varTheta _{\beta }$, where $\varTheta _{\lambda }$ is a closed convex subset of $C[0,\tau ]$ and $\varTheta _{\beta }$ is a compact set in ${\mathbb{R}}^{m}$. The estimator is consistent and asymptotically normal. In the present paper, we construct confidence intervals for integral functionals of $\lambda (\cdot )$ and a confidence region for β under restrictions on the error distribution. In particular, we handle the following cases: (a) the measurement error is bounded, (b) it is a normally distributed random vector, and (c) it has independent components which are shifted Poisson random variables.

References

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Augustin, T.: An exact corrected log-likelihood function for Cox’s proportional hazards model under measurement error and some extensions. Scand. J. Statist. 31(1), 43–50 (2004). doi:https://doi.org/10.1111/j.1467-9469.2004.00371.x. MR2042597
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Chimisov, C., Kukush, A.: Asymptotic normality of corrected estimator in Cox proportional hazards model with measurement error. Mod. Stoch. Theory Appl. 1(1), 13–32 (2014). doi:https://doi.org/10.15559/vmsta-2014.1.1.3. MR3314791
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Kukush, A., Baran, S., Fazekas, I., Usoltseva, E.: Simultaneous estimation of baseline hazard rate and regression parameters in Cox proportional hazards model with measurement error. J. Statist. Res. 45(2), 77 (2011). MR2934363
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Kukush, A., Chernova, O.: Consistent estimation in Cox proportional hazards model with measurement errors and unbounded parameter set. arXiv preprint arXiv:1703.10940 (2017). MR3666874
[7] 
Kukush, A., Chernova, O.: Consistent estimation in Cox proportional hazards model with measurement errors and unbounded parameter set (Ukrainian). Teor. Imovir. Mat. Stat. 96, 100–109 (2017). MR3666874
[8] 
Stefanski, L.A.: Unbiased estimation of a nonlinear function of a normal mean with application to measurement error models. Comm. Statist. Theory Methods 18(12), 4335–4358 (1990). MR1046712

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Keywords
Asymptotic normality confidence region consistent estimator Cox proportional hazards model measurement errors simultaneous estimation of baseline hazard rate and regression parameter

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